Pou3f3 Gene Summary [Mouse]
Enables HMG box domain binding activity and sequence-specific DNA binding activity. Involved in several processes, including metanephric nephron epithelium development; negative regulation of apoptotic process; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including forebrain development; positive regulation of transcription by RNA polymerase II; and urea transmembrane transport. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; phalanx; and sensory organ. Orthologous to human POU3F3 (POU class 3 homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pou3f3 |
| Official Name | POU domain, class 3, transcription factor 3 [Source:MGI Symbol;Acc:MGI:102564] |
| Ensembl ID | ENSMUSG00000045515 |
| Bio databases IDs | |
| Aliases | POU domain, class 3, transcription factor 3 |
| Synonyms | Brain1, BRN1, HST011, oct-8, OTF8, POU class 3 homeobox 3, POU domain, class 3, transcription factor 3, RHS1, Skin1, SNIBFIS, urehr2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pou3f3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pou domain - N-terminal to homeobox domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- protein homodimerization
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- Snijders Blok-Fisher syndrome
- developmental delay
- developmental disorder
- mental retardation
- complex neurodevelopmental disorder
role in cell
- proliferation
- apoptosis
- differentiation
- migration
- lamination
- loss
- production
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pou3f3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- forebrain ventricular zone progenitor cell division
- urea transmembrane transport
- positive regulation of cell proliferation
- chemical homeostasis
- cerebral cortex radially oriented cell migration
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- metanephric DCT cell differentiation
- central nervous system development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- metanephric thick ascending limb development
- positive regulation of gene expression
- metanephric macula densa development
- metanephric loop of Henle development
- metanephric ascending thin limb development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- HMG box domain binding
- sequence-specific DNA binding transcription factor activity
- protein homodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity