Ifitm5

Involved in bone mineralization; bone morphogenesis; and in utero embryonic development. Acts upstream of or within response to rapamycin; response to tacrolimus; and skeletal system development. Located in plasma membrane. Is expressed in several structures, including bone; genitourinary system; limb cartilage condensation; perichondrium; and spleen. Used to study osteogenesis imperfecta type 5. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 5. Orthologous to human IFITM5 (interferon induced transmembrane protein 5). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifitm5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ifitm5 gene, providing context for its role in the cell.