Wdr73 Gene Summary [Mouse]
Predicted to be involved in cytoplasmic microtubule organization; negative regulation of apoptotic process; and nucleus organization. Predicted to colocalize with cleavage furrow; cytosol; and spindle pole. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 1. Orthologous to human WDR73 (WD repeat domain 73). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr73 |
| Official Name | WD repeat domain 73 [Source:MGI Symbol;Acc:MGI:1919218] |
| Ensembl ID | ENSMUSG00000025722 |
| Bio databases IDs | |
| Aliases | WD repeat domain 73 |
| Synonyms | 1200011I23Rik, 2410008B13Rik, GAMOS, GAMOS1, HSPC264, Neuromedin-b, WD repeat domain 73 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr73 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Galloway Mowat syndrome 1
- hereditary disorder
- nephrosis
- albuminuria
- dystonia
- sarcoidosis
- periodontitis
regulated by
- estrogen
- NFE2L2
- dexamethasone
- sulforafan
role in cell
- production in
- apoptosis
- expression in
- formation
- organization
- formation in
- degradation in
- G2/M phase
- injury
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cytosol
- spindle pole
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr73 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- cytoplasmic microtubule organization
- nucleus organization
Cellular Component
Where in the cell the gene product is active
- cleavage furrow
- spindle pole
- cytosol