Prkcb Gene Summary [Mouse]
Enables calcium channel regulator activity and calcium,diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; and positive regulation of cell communication. Acts upstream of or within several processes, including cellular response to carbohydrate stimulus; intracellular calcium ion homeostasis; and protein phosphorylation. Located in cytoplasm and nucleus. Part of spectrin. Is active in calyx of Held; plasma membrane; and presynaptic cytosol. Is expressed in several structures, including central nervous system; exocrine system; genitourinary system; heart ventricle; and retina. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Prkcb |
| Official Name | protein kinase C, beta [Source:MGI Symbol;Acc:MGI:97596] |
| Ensembl ID | ENSMUSG00000052889 |
| Bio databases IDs | |
| Aliases | protein kinase C, beta |
| Synonyms | A130082F03Rik, PKC-B, PKC-Beta, PKCbetaI, PKCI(2), PKC Type II, PKC Type III, PKC-β, PKC β 1, PKCβI, Prkcb1, PRKCB2, protein kinase C beta, protein kinase C, beta, protein kinase C β, protein kinase C, β, protein kinase c, β 1 polypeptide, protein kinase C β II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkcb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- transcription co-activator
- regulatory domain
- ATP-binding domain
- androgen receptor binding
- C1A domain
- chromatin binding
- V domain
- enzyme
- Turn motif
- Protein kinase domain
- activation loop
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- protein kinase C
- Tyrosine kinase, catalytic domain
- C2 domain
- histone binding
- Protein kinase (unclassified specificity)
- C1C2 domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein kinase C binding
- protein binding
- autophosphorylation site
- calcium channel regulator
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- calcium dependent protein kinase C
- Protein Kinases, catalytic domain
- pseudosubstrate domain
- C1B domain
- Protein kinase C conserved region 2 (CalB)
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Prkcb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Chemokine Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ErbB4 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Fc Epsilon RI Signaling
- Glioma Signaling
- GM-CSF Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- Mechanisms of Viral Exit from Host Cells
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Activation by Viruses
- NF-κB Signaling
- nNOS Signaling in Neurons
- Prolactin Signaling
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VDR/RXR Activation
- VEGF Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mantle cell lymphoma
- cancer
- epithelial neoplasia
- bipolar disorder
- diabetic retinopathy
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- endometriosis
- hyperplasia
regulated by
- TNF
- eicosapentaenoic acid
- arachidonic acid
- docosahexaenoic acid
- hydrogen peroxide
- D-glucose
- vp3
- tetradecanoylphorbol acetate
- propranolol
- calcitriol
role in cell
- activation in
- accumulation in
- expression in
- proliferation
- phosphorylation in
- morphology
- recruitment in
- survival
- apoptosis
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- detergent-insoluble fractions
- membrane fraction
- cytoskeleton
- cell periphery
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- Plasma Membrane
- centrosome
- granules
- cytosol
- apical membrane
- nucleoplasm
- nuclear envelope
- growth cone
- neurites
- nerve ending
- synaptosomes
- brush border
- perikaryon
- axons
- axon terminals
- melanosomal membrane
- apical processes
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkcb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to vitamin D
- mitotic nuclear envelope disassembly
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- response to xenobiotic stimulus
- B cell activation
- protein phosphorylation
- post-translational protein modification
- positive regulation of angiogenesis
- lipoprotein transport
- response to ethanol
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
- chromatin remodeling
- response to glucose stimulus
- positive regulation of transcription, DNA-dependent
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- calcium ion transport
- apoptotic process
- positive regulation of insulin secretion
- dibenzo-p-dioxin metabolic process
- intracellular signal transduction
- B cell receptor signaling pathway
- regulation of dopamine secretion
- signal transduction
- adaptive immune response
- positive regulation of odontogenesis of dentin-containing tooth
- regulation of growth
- negative regulation of insulin receptor signaling pathway
- cellular calcium ion homeostasis
- regulation of transcription from RNA polymerase II promoter
- positive regulation of B cell receptor signaling pathway
- regulation of glucose transport
- negative regulation of glucose transport
- cellular response to carbohydrate stimulus
- regulation of synaptic vesicle exocytosis
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- brush border membrane
- extracellular vesicular exosome
- cytoplasm
- cytosol
- spectrin
- plasma membrane
- calyx of Held
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- zinc ion binding
- chromatin binding
- calcium channel regulator activity
- protein serine/threonine kinase activity
- protein kinase C activity
- ATP binding
- protein binding
- androgen receptor binding
- histone binding
- ligand-dependent nuclear receptor transcription coactivator activity
- histone kinase activity (H3-T6 specific)