Tk1 Gene Summary [Mouse]
Enables thymidine kinase activity. Predicted to be involved in DNA synthesis involved in mitotic DNA replication; protein homotetramerization; and thymidine biosynthetic process. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and hemolymphoid system. Orthologous to human TK1 (thymidine kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tk1 |
| Official Name | thymidine kinase 1 [Source:MGI Symbol;Acc:MGI:98763] |
| Ensembl ID | ENSMUSG00000025574 |
| Bio databases IDs | |
| Aliases | thymidine kinase 1 |
| Synonyms | D530002A18Rik, Thymidine Kinase 1, Tk, Tk1a, Tk1b, TK2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- zinc ion binding
- protein binding
- identical protein binding
- thymidine kinase
- KEN box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
- B cell cancer
- COVID-19
- lung adenocarcinoma
- lung adenocarcinoma formation
- soft tissue sarcoma cancer
- liver cancer
- arteritis
role in cell
- apoptosis
- expression in
- number
- proliferation
- G1 phase
- migration
- cell death
- differentiation
- accumulation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- thymidine biosynthetic process
- thymidine metabolic process
- deoxyribonucleoside monophosphate biosynthetic process
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- zinc ion binding
- protein binding
- thymidine kinase activity