Sntg1 Gene Summary [Mouse]
Predicted to enable actin binding activity and structural molecule activity. Predicted to be located in cytoplasm; cytoskeleton; and ruffle membrane. Predicted to be part of dystrophin-associated glycoprotein complex. Orthologous to human SNTG1 (syntrophin gamma 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sntg1 |
| Official Name | syntrophin, gamma 1 [Source:MGI Symbol;Acc:MGI:1918346] |
| Ensembl ID | ENSMUSG00000025909 |
| Bio databases IDs | |
| Aliases | syntrophin, gamma 1 |
| Synonyms | 4933426D16Rik, G1SYN, LOC102556371, LOC102724295, RGD1560290, SYN4, Syntrophin Gamma1, syntrophin, gamma 1, syntrophin γ 1, syntrophin, γ 1, γ 1 Syn |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sntg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- P-loop
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- PH domain
- protein binding
- Pleckstrin homology-like domain
- PDZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial ovarian cancer
- idiopathic scoliosis
- acute myeloid leukemia
- obstructive sleep apnea
- diabetic nephropathy
- ovarian carcinoma
role in cell
- formation
- communication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- somatodendritic region
- cellular membrane
- Nucleus
- Plasma Membrane
- membrane ruffles
- myelin sheath outer loop
- paranodal loops
- myelin sheath inner loop
- Schmidt-Lanterman incisures
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sntg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell communication
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- dystrophin-associated glycoprotein complex
- ruffle membrane
- syntrophin complex
- intracellular
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- structural molecule activity