Dtnb Gene Summary [Mouse]
Enables DNA binding activity. Predicted to be involved in neuron differentiation and synaptic signaling. Located in cytoplasm; inhibitory synapse; and nucleus. Is active in GABA-ergic synapse and postsynapse. Orthologous to human DTNB (dystrobrevin beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dtnb |
| Official Name | dystrobrevin, beta [Source:MGI Symbol;Acc:MGI:1203728] |
| Ensembl ID | ENSMUSG00000071454 |
| Bio databases IDs | |
| Aliases | dystrobrevin, beta |
| Synonyms | dystrobrevin beta, dystrobrevin, beta, dystrobrevin β, dystrobrevin, β, β dystrobrevin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dtnb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- ZZ
- EF hand
- EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
- Uso1 / p115 like vesicle tethering protein, C terminal region
- coiled-coil domain
- zinc finger domain
- protein binding
- Cell division protein ZapB
- DNA binding
- JNK_SAPK-associated protein-1
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- plasma cell myeloma
- lung adenocarcinoma
- lung adenocarcinoma formation
- cutaneous melanoma
- cutaneous melanoma cancer
- Crohn disease
role in cell
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- soluble fraction
- postsynaptic density (PSD) fractions
- Cytoplasm
- postsynaptic region
- Nucleus
- microsome
- basolateral membrane
- synapse
- perikaryon
- axons
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dtnb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
Cellular Component
Where in the cell the gene product is active
- inhibitory synapse
- dendrite
- nucleus
- postsynaptic density
- basal plasma membrane
- cytoplasm
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding