Adhfe1 Gene Summary [Mouse]
Predicted to enable alcohol dehydrogenase (NAD+) activity and hydroxyacid-oxoacid transhydrogenase activity. Predicted to be involved in glutamate catabolic process via 2-hydroxyglutarate. Located in mitochondrion. Is expressed in several structures, including brain; cranium; genitourinary system; sensory organ; and spinal cord. Orthologous to human ADHFE1 (alcohol dehydrogenase iron containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adhfe1 |
| Official Name | alcohol dehydrogenase, iron containing, 1 [Source:MGI Symbol;Acc:MGI:1923437] |
| Ensembl ID | ENSMUSG00000025911 |
| Bio databases IDs | |
| Aliases | alcohol dehydrogenase, iron containing, 1 |
| Synonyms | 6330565B14Rik, ADH8, alcohol dehydrogenase iron containing 1, alcohol dehydrogenase, iron containing, 1, GHB dehydrogenase, HMFT2263, HOT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adhfe1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alcohol dehydrogenase
- enzyme
- dehydroquinate synthase-like
- Iron-containing alcohol dehydrogenase
- hydroxyacid-oxoacid transhydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adhfe1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate catabolic process via 2-oxoglutarate
- lipid metabolic process
- 2-oxoglutarate metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- alcohol dehydrogenase (NAD) activity
- hydroxyacid-oxoacid transhydrogenase activity