Bag3 Gene Summary [Mouse]
Predicted to enable adenyl-nucleotide exchange factor activity and protein-folding chaperone binding activity. Involved in muscle cell cellular homeostasis. Acts upstream of or within several processes, including cellular response to mechanical stimulus; extrinsic apoptotic signaling pathway in absence of ligand; and protein stabilization. Located in Z disc. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study dilated cardiomyopathy 1HH. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2JJ; autosomal dominant distal hereditary motor neuronopathy 15; dilated cardiomyopathy 1HH; and myofibrillar myopathy 6. Orthologous to human BAG3 (BAG cochaperone 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bag3 |
| Official Name | BCL2-associated athanogene 3 [Source:MGI Symbol;Acc:MGI:1352493] |
| Ensembl ID | ENSMUSG00000030847 |
| Bio databases IDs | |
| Aliases | BCL2-associated athanogene 3 |
| Synonyms | BAG cochaperone 3, BCL2-associated athanogene 3, BIS, CAIR-1, MFM6, mg638 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bag3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IxI/V motif
- adenyl-nucleotide exchange factor
- Domain with 2 conserved Trp (W) residues
- BAG domains, present in regulator of Hsp70 proteins
- binding protein
- WW
- BAG domain
- protein binding
- chaperone binding
- PXXP motif
- WW domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- heart failure
- systolic heart failure
- hepatic steatosis
- cardiomyopathy
- epileptic seizure
- autosomal dominant distal hereditary motor neuropathy
- chronic obstructive pulmonary disease
- BAG3-related myofibrillar myopathy
- breast cancer
phenotypes
- decreased blood urea nitrogen level
- decreased lean body mass
- decreased monocyte cell number
- preweaning lethality complete penetrance
- abnormal Z line morphology
- abnormal blood urea nitrogen level
- abnormal lean body mass
- abnormal skeletal muscle morphology
- decreased body weight
- decreased circulating cholesterol level
- decreased circulating insulin level
- decreased circulating triglyceride level
- decreased gonadal fat pad weight
- decreased leukocyte cell number
- decreased liver weight
- decreased lymphocyte cell number
- decreased neutrophil cell number
- decreased spleen weight
- decreased subcutaneous adipose tissue amount
- decreased thymus weight
- disproportionate dwarf
- hepatic steatosis
- hypoglycemia
- increased body weight
- increased cardiomyocyte apoptosis
- increased circulating ketone body level
- increased grip strength
- myocardial fiber degeneration
- pale liver
- postnatal growth retardation
- postnatal lethality
- postnatal lethality complete penetrance
- premature death
- pulmonary edema
- skeletal muscle fiber degeneration
- spleen hypoplasia
- thymus hypoplasia
- tremors
- weight loss
role in cell
- phosphorylation in
- expression in
- ubiquitination in
- apoptosis
- binding in
- degradation in
- accumulation in
- activation in
- transactivation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- Nucleus
- basal bodies
- Mitochondria
- myofilaments
- cytosol
- nucleoplasm
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bag3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle cell homeostasis
- positive regulation of protein import into nucleus
- positive regulation of protein export from nucleus
- extrinsic apoptotic signaling pathway in absence of ligand
- protein folding
- induction of apoptosis via death domain receptors
- autophagic vacuole assembly
- cellular response to mechanical stimulus
- cellular response to heat
- striated muscle cell apoptotic process
- negative regulation of apoptotic process
- aggresome assembly
- cellular response to unfolded protein
- protein stabilization
- negative regulation of striated muscle cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- cytoplasm
- membrane
- stress fiber
- cytosol
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- chaperone binding
- adenyl-nucleotide exchange factor activity
- dynein intermediate chain binding