Mdh1b Gene Summary [Mouse]
Predicted to enable L-malate dehydrogenase (NAD+) activity. Predicted to be involved in NADH metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Is expressed in cerebral cortex; heart; and liver. Orthologous to human MDH1B (malate dehydrogenase 1B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mdh1b |
| Official Name | malate dehydrogenase 1B, NAD (soluble) [Source:MGI Symbol;Acc:MGI:1923918] |
| Ensembl ID | ENSMUSG00000025963 |
| Bio databases IDs | |
| Aliases | malate dehydrogenase 1B, NAD (soluble) |
| Synonyms | 1700124B08RIK, LOC130752, malate dehydrogenase 1B, malate dehydrogenase 1B, NAD (soluble), RP11-95H11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mdh1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- malate dehydrogenase, NADP-dependent
- enzyme
- lactate/malate dehydrogenase, alpha/beta C-terminal domain
- lactate dehydrogenase
- malate dehydrogenase, NAD-dependent
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mdh1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- NADH metabolic process
- oxaloacetate metabolic process
- malate metabolic process
- tricarboxylic acid cycle
Molecular Function
What the gene product does at the molecular level
- L-malate dehydrogenase activity