Epha3 Gene Summary [Mouse]
Enables ephrin receptor activity and growth factor binding activity. Involved in several processes, including axonal fasciculation; ephrin receptor signaling pathway; and synaptic membrane adhesion. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus; negative regulation of neuron projection development; and regulation of cell migration. Is active in GABA-ergic synapse and presynapse. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human EPHA3 (EPH receptor A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epha3 |
| Official Name | Eph receptor A3 [Source:MGI Symbol;Acc:MGI:99612] |
| Ensembl ID | ENSMUSG00000052504 |
| Bio databases IDs | |
| Aliases | Eph receptor A3 |
| Synonyms | Cek4, EK4, END3, EPH receptor A3, ETK, ETK1, HEK, HEK4, Mek4, TYRO4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epha3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tyrosine-protein kinase ephrin type A/B receptor-like
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- GPI-linked ephrin receptor
- Sterile alpha motif
- ligand-binding domain
- SAM domain (Sterile alpha motif)
- Tyrosine kinase, catalytic domain
- growth factor binding
- cysteine rich domain
- Ligand Binding Domain of Ephrin Receptors
- extracellular domain
- Protein kinase (unclassified specificity)
- dimerization domain
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- Purple acid Phosphatase, N-terminal domain
- ephrin receptor
- protein binding
- EGF-like domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- FN3
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the Epha3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- bleeding
- pancreatic cancer
- atrial fibrillation
- congestive heart failure
- lung adenocarcinoma
- lung adenocarcinoma formation
- medullary thyroid carcinoma
- medullary thyroid cancer
- natural killer/T-cell lymphoma
role in cell
- proliferation
- binding
- apoptosis
- expression in
- migration
- invasion by
- binding in
- adhesion
- assembly
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- Extracellular Space
- cellular membrane
- actin cytoskeleton
- cytosol
- nucleoplasm
- nuclear envelope
- synapse
- early endosomes
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Epha3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- negative regulation of endocytosis
- regulation of microtubule cytoskeleton organization
- axon guidance
- cell adhesion
- protein phosphorylation
- fasciculation of sensory neuron axon
- regulation of epithelial to mesenchymal transition
- regulation of focal adhesion assembly
- regulation of actin cytoskeleton organization
- fasciculation of motor neuron axon
- cellular response to retinoic acid
- ephrin receptor signaling pathway
- regulation of GTPase activity
- positive regulation of neuron projection development
- cell migration
Cellular Component
Where in the cell the gene product is active
- dendrite
- nuclear membrane
- early endosome
- actin cytoskeleton
- cytosol
- extracellular region
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- GPI-linked ephrin receptor activity
- ephrin receptor activity
- transmembrane-ephrin receptor activity