Ddx5 Gene Summary [Mouse]
Enables RNA binding activity; promoter-specific chromatin binding activity; and transcription coregulator activity. Involved in several processes, including RNA metabolic process; regulation of alternative mRNA splicing, via spliceosome; and regulation of osteoblast differentiation. Acts upstream of or within circadian rhythm; positive regulation of DNA-templated transcription; and protein import into nucleus. Predicted to be located in nuclear speck and nucleolus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DDX5 (DEAD-box helicase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx5 |
| Official Name | DEAD box helicase 5 [Source:MGI Symbol;Acc:MGI:105037] |
| Ensembl ID | ENSMUSG00000020719 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 5 |
| Synonyms | 2600009A06RIK, Dead5, DEAD-box helicase 5, Dead box polypeptide 5, DEAD-box protein p68, G17P1, HELR, HLR1, HUMP68, MGC93965, p68, p68 RNA Helicase, RNA helicase p68 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- SMAD binding
- calmodulin binding
- P68HR (NUC004) repeat
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- transcription cofactor
- androgen receptor binding
- enzyme binding
- chromatin binding
- protein domain specific binding
- enzyme
- protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- RNA binding
- mRNA 3' UTR binding
- ribonucleoprotein binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Ddx5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- neoplasia
- cancer
- lung cancer
- epithelial cancer
- epithelial neoplasia
- adrenal cortex carcinoma
- fibrosis
- colon cancer
role in cell
- proliferation
- growth
- expression in
- consumption in
- synthesis in
- apoptosis
- production in
- quantity
- downregulation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- catalytic step 2 spliceosome
- Cytoplasm
- cytosol
- spliceosomes
- inner nuclear membrane
- nucleoplasm
- nucleoli
- nuclear rim
- interchromatin granule clusters
- nuclear speckles
- chromatin
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- primary miRNA processing
- mRNA transcription
- nuclear-transcribed mRNA catabolic process
- myoblast differentiation
- regulation of viral genome replication
- regulation of osteoblast differentiation
- regulation of androgen receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
- nuclear mRNA splicing, via spliceosome
- negative regulation of transcription from RNA polymerase II promoter
- rhythmic process
- regulation of alternative nuclear mRNA splicing, via spliceosome
- signal transduction by p53 class mediator resulting in induction of apoptosis
- BMP signaling pathway
- alternative nuclear mRNA splicing, via spliceosome
- epithelial to mesenchymal transition
- androgen receptor signaling pathway
- intracellular estrogen receptor signaling pathway
- regulation of skeletal muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- catalytic step 2 spliceosome
- cytoplasm
- nuclear speck
- membrane
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- pre-mRNA binding
- calcium-dependent protein binding
- mRNA 3'-UTR binding
- ATP binding
- calmodulin binding
- protein binding
- RNA binding
- SMAD binding
- androgen receptor binding
- RNA helicase activity
- ribonucleoprotein complex binding
- R-SMAD binding
- primary miRNA binding
- MH2 domain binding
- enzyme binding