Eef1b2 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity and translation elongation factor activity. Predicted to be involved in response to ethanol and translational elongation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Predicted to colocalize with endoplasmic reticulum. Is expressed in several structures, including brain; exocrine gland; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human EEF1B2 (eukaryotic translation elongation factor 1 beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eef1b2 |
| Official Name | eukaryotic translation elongation factor 1 beta 2 [Source:MGI Symbol;Acc:MGI:1929520] |
| Ensembl ID | ENSMUSG00000025967 |
| Bio databases IDs | |
| Aliases | eukaryotic translation elongation factor 1 beta 2 |
| Synonyms | 2810017J07Rik, EEF1B, EEF1B1, EF1B, EF-1-beta, EF-1-β, ELONGATION FACTOR 1 beta, ELONGATION FACTOR 1 β, eukaryotic translation elongation factor 1 beta 2, eukaryotic translation elongation factor 1 β 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eef1b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic elongation factor 1 beta central acidic region
- translation elongation factor
- protein binding
- EF-1 guanine nucleotide exchange domain
- EF1B
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- autosomal recessive nonsyndromic mental retardation
- chronic kidney disease
- global developmental delay
regulates
- aminoacyl-tRNA
- GDP
role in cell
- apoptosis
- survival
- proliferation
- binding
- ceralasertib resistance
- berzosertib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- perinuclear region
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eef1b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- translational elongation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- endoplasmic reticulum
- eukaryotic translation elongation factor 1 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- translation elongation factor activity
- guanyl-nucleotide exchange factor activity