Cdk9 Gene Summary [Mouse]
Enables several functions, including RNA polymerase II CTD heptapeptide repeat kinase activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein kinase binding activity. Involved in regulation of mRNA 3'-end processing. Located in nucleus. Part of cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human CDK9 (cyclin dependent kinase 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cdk9 |
| Official Name | cyclin-dependent kinase 9 (CDC2-related kinase) [Source:MGI Symbol;Acc:MGI:1328368] |
| Ensembl ID | ENSMUSG00000009555 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 9 (CDC2-related kinase) |
| Synonyms | C-2k, CDC2L4, CTK1, cyclin-dependent kinase 9, PITALRE, TAK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdk9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase
- [RNA-polymerase]-subunit kinase
- snRNA binding
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- nucleic acid binding
- transcription factor binding
- chromatin binding
- protein binding
- Protein kinase domain
- sequence-specific DNA binding
- activation loop
- DNA binding
- transcriptional elongation regulator
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- double-stranded DNA binding
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Cdk9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriatic arthritis
- chronic lymphocytic leukemia
regulated by
- lipopolysaccharide
- STAT3
- adenosine triphosphate
- paroxetine
- human respiratory syncytial virus A2
- geldanamycin
- NEF
- tetradecanoylphorbol acetate
- 26S proteasome
- TCR (complex)
role in cell
- expression in
- production in
- phosphorylation in
- differentiation
- binding in
- apoptosis
- proliferation
- growth
- cell proliferation
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear speckles
- PML nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdk9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- positive regulation by host of viral transcription
- DNA repair
- regulation of DNA repair
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- regulation of mitotic cell cycle
- transcription initiation from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
- positive regulation of transcription elongation from RNA polymerase II promoter
- regulation of muscle cell differentiation
- regulation of mRNA 3'-end processing
- cellular response to cytokine stimulus
- replication fork processing
- regulation of cell cycle
- nucleus localization
Cellular Component
Where in the cell the gene product is active
- dimeric positive transcription elongation factor complex b
- nucleus
- PML body
- transcription elongation factor complex
- membrane
- positive transcription elongation factor complex b
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- RNA polymerase II carboxy-terminal domain kinase activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein kinase activity
- cyclin-dependent protein kinase activity
- chromatin binding
- protein serine/threonine kinase activity
- transcription coactivator binding
- DNA binding
- ATP binding
- transcription elongation regulator activity
- protein binding
- kinase activity