Ankzf1 Gene Summary [Mouse]
Predicted to enable RNA endonuclease activity and catalytic activity, acting on a tRNA. Predicted to be involved in cellular response to hydrogen peroxide; proteolysis involved in protein catabolic process; and rescue of stalled ribosome. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Orthologous to human ANKZF1 (ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ankzf1 |
| Official Name | ankyrin repeat and zinc finger domain containing 1 [Source:MGI Symbol;Acc:MGI:1098746] |
| Ensembl ID | ENSMUSG00000026199 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and zinc finger domain containing 1 |
| Synonyms | 1300008P06Rik, 2810025E10Rik, ankyrin repeat and zinc finger domain containing 1, ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1, Ankz1, D1Ertd161e, RGD1359242, Vms1, ZNF744 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ankzf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vms1-associating treble clef domain
- Bacteroidetes VLRF1 release factor
- transcription regulator
- Ankyrin repeats (many copies)
- endoribonuclease
- U1 zinc finger
- protein binding
- enzyme
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ankzf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- misfolded or incompletely synthesized protein catabolic process
- rescue of stalled ribosome
- cellular response to hydrogen peroxide
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- endoribonuclease activity