Asb1 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within male genitalia development. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB1 (ankyrin repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asb1 |
| Official Name | ankyrin repeat and SOCS box-containing 1 [Source:MGI Symbol;Acc:MGI:1929735] |
| Ensembl ID | ENSMUSG00000026311 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and SOCS box-containing 1 |
| Synonyms | 1700029O08Rik, 1700054C17Rik, ankyrin repeat and SOCS box-containing 1, mKIAA1146 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Asb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- transcription regulator
- Ankyrin repeats (many copies)
- ubiquitin protein ligase activity
- Ankyrin repeats (3 copies)
- SOCS
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Asb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male genitalia development
- negative regulation of cytokine production
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding