ASB1 Gene Summary [Human]
The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016]
Details
| Type | Processed Transcript |
| Official Symbol | ASB1 |
| Official Name | ankyrin repeat and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:16011] |
| Ensembl ID | ENSG00000065802 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and SOCS box containing 1 |
| Synonyms | 1700029O08Rik, 1700054C17Rik, ankyrin repeat and SOCS box-containing 1, mKIAA1146 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ASB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- transcription regulator
- Ankyrin repeats (many copies)
- ubiquitin protein ligase activity
- Ankyrin repeats (3 copies)
- SOCS
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ASB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male genitalia development
- negative regulation of cytokine production
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding