Kat5 Gene Summary [Mouse]
Enables chromatin binding activity; histone acetyltransferase activity; and transcription coactivator activity. Involved in several processes, including nervous system development; positive regulation of regulatory T cell differentiation; and sperm DNA condensation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Part of NuA4 histone acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kat5 |
| Official Name | K(lysine) acetyltransferase 5 [Source:MGI Symbol;Acc:MGI:1932051] |
| Ensembl ID | ENSMUSG00000024926 |
| Bio databases IDs | |
| Aliases | K(lysine) acetyltransferase 5 |
| Synonyms | CPLA2, ESA1, HTATIP, HTATIP1, K(lysine) acetyltransferase 5, lysine acetyltransferase 5, NEDFASB, PLIP, TIP, Tip55, TIP60, ZC2HC5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kat5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- zinc finger DNA binding domain
- histone acetyltransferase domain
- LXXLL motif
- histone lysine acetyltransferase activity (H4-K16 specific)
- transcription co-activator
- Sumoylation motif
- MOZ/SAS family
- transcription factor binding
- cdk phosphorylation site
- chromatin binding
- enzyme
- zDHHC ankyrin repeat binding domain
- histone acetyltransferase
- N-acyltransferase
- catalytic domain
- NAT_SF
- enzyme binding
- protein binding
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- N-acetyltransferase
- binding protein
- zinc finger domain
- acetyltransferase
- MYST family zinc finger domain
Pathways
Biological processes and signaling networks where the Kat5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities
- hepatocellular carcinoma
- liver cancer
- organismal death
- acute myeloid leukemia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- experimental Alzheimer disease
role in cell
- proliferation
- survival
- differentiation
- production in
- expression in
- apoptosis
- activation in
- cell viability
- transcription in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- membrane fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cytosol
- nucleosomes
- nucleoplasm
- nucleoli
- spindle pole
- PML nuclear bodies
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kat5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- negative regulation of double-strand break repair via homologous recombination
- cellular senescence
- nucleotide-excision repair
- positive regulation of myoblast differentiation
- neurogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of circadian rhythm
- double-strand break repair
- negative regulation of transcription from RNA polymerase II promoter
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- positive regulation of regulatory T cell differentiation
- cellular response to estradiol stimulus
- negative regulation of interleukin-2 production
- peptidyl-lysine acetylation
- negative regulation of transcription, DNA-dependent
- cellular response to glucose stimulus
- regulation of double-strand break repair
- positive regulation of transcription, DNA-dependent
- apoptotic process
- regulation of cell cycle
- response to ionizing radiation
- spermatid development
- double-strand break repair via homologous recombination
- sperm chromatin condensation
- regulation of apoptotic process
- response to DNA damage stimulus
- cellular response to glucose starvation
- regulation of transcription from RNA polymerase II promoter
- positive regulation of autophagy
- establishment of mitotic spindle orientation
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of triglyceride biosynthetic process
- innate immune response
Cellular Component
Where in the cell the gene product is active
- NuA4 histone acetyltransferase complex
- site of double-strand break
- Swr1 complex
- kinetochore
- nucleosome
- nucleolus
- chromatin
- nucleoplasm
- nucleus
- transcription factor complex
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- Piccolo NuA4 histone acetyltransferase complex
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity (H2A-K5 specific)
- histone acetyltransferase activity
- transcription cofactor activity
- protein binding
- acetyltransferase activity
- transcription coactivator activity
- metal ion binding
- histone acetyltransferase activity (H4-K16 specific)
- chromatin binding
- H4 histone acetyltransferase activity
- H2A histone acetyltransferase activity