Eloc Gene Summary [Mouse]
Predicted to enable protein-macromolecule adaptor activity and transcription corepressor binding activity. Predicted to be involved in RNA metabolic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Part of Cul5-RING ubiquitin ligase complex and elongin complex. Is expressed in several structures, including alimentary system; cerebral cortex; ganglia; musculature; and nose. Orthologous to human ELOC (elongin C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eloc |
| Official Name | elongin C [Source:MGI Symbol;Acc:MGI:1915173] |
| Ensembl ID | ENSMUSG00000079658 |
| Bio databases IDs | |
| Aliases | elongin C |
| Synonyms | 2610043E24Rik, 2610301I15RIK, Elongation Factor SIII p15 Subunit, Elongin-C, SIII, SIII p15, TCEB1, Tcebf1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eloc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- binding protein
- BTB_POZ
- transcription factor binding
- protein binding
Pathways
Biological processes and signaling networks where the Eloc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- breast cancer
- renal cell carcinoma
- renal cell cancer
- Waldenström macroglobulinemia
- infection by HIV-1
role in cell
- apoptosis
- accumulation in
- turnover in
- polyubiquitination in
- degradation in
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eloc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription initiation from RNA polymerase II promoter
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- Cul2-RING ubiquitin ligase complex
- elongin complex
- Cul5-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- protein binding
- protein binding, bridging