Eif2d Gene Summary [Mouse]
Predicted to enable translation initiation factor activity. Predicted to be involved in IRES-dependent viral translational initiation; formation of translation preinitiation complex; and ribosome disassembly. Predicted to be located in cytosol and nuclear body. Predicted to be part of cytosolic small ribosomal subunit. Orthologous to human EIF2D (eukaryotic translation initiation factor 2D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Eif2d |
| Official Name | eukaryotic translation initiation factor 2D [Source:MGI Symbol;Acc:MGI:109342] |
| Ensembl ID | ENSMUSG00000026427 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 2D |
| Synonyms | D1Ertd5e, eukaryotic translation initiation factor 2D, HCA56, LGTN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PUA RNA binding domain
- arCOG04150 universal archaeal PUA-domain protein
- PUA domain
- signaling receptor activity
- eIF2D_N_like
- Translation initiation factor SUI1
- translation initiation factor
- uncharacterized domain 2
- Pre-PUA-like domain
- transporter
- Eukaryotic initiation factor 1 and related proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- ribosome
- Plasma Membrane
- cytosol
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif2d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation preinitiation complex
- ribosome disassembly
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasm
- cytosolic small ribosomal subunit
- cytosol
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA binding
- signaling receptor activity