Slc45a3 Gene Summary [Mouse]
Enables sucrose:proton symporter activity. Involved in positive regulation of fatty acid biosynthetic process; positive regulation of glucose metabolic process; and regulation of oligodendrocyte differentiation. Acts upstream of or within sucrose transport. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Orthologous to human SLC45A3 (solute carrier family 45 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc45a3 |
| Official Name | solute carrier family 45, member 3 [Source:MGI Symbol;Acc:MGI:1922082] |
| Ensembl ID | ENSMUSG00000026435 |
| Bio databases IDs | |
| Aliases | solute carrier family 45, member 3 |
| Synonyms | 2210413P12Rik, IPCA-2, IPCA-6, IPCA-8, PCANAP2, PCANAP6, PCANAP8, Prostein, PRST, RGD1309764, solute carrier family 45 member 3, solute carrier family 45, member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc45a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carbohydrate transporter
- Major Facilitator Superfamily
- sucrose:hydrogen symporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- hepatocellular carcinoma
- cleft lip
- epithelial cancer
- prostate cancer
- prostatic carcinoma
- liver cancer
regulates
- SLC45A3
- alpha-D-glucose
- hexose
- sucrose
- fatty acid
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc45a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of glucose metabolic process
- sucrose transport
- regulation of oligodendrocyte differentiation
- hexose transport
- positive regulation of fatty acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sucrose:hydrogen symporter activity
- sugar transmembrane transporter activity