Chit1 Gene Summary [Mouse]
Predicted to enable endochitinase activity. Predicted to be involved in chitin catabolic process. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Orthologous to human CHIT1 (chitinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chit1 |
| Official Name | chitinase 1 (chitotriosidase) [Source:MGI Symbol;Acc:MGI:1919134] |
| Ensembl ID | ENSMUSG00000026450 |
| Bio databases IDs | |
| Aliases | chitinase 1 (chitotriosidase) |
| Synonyms | 2300002L19Rik, CHI3, CHIT, CHITD, chitinase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chit1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chitinase
- Glycosyl hydrolases family 18
- Chitin binding Peritrophin-A domain
- glycosidase
- GH18_chitinase-like
- endochitinase
- enzyme
- protein binding
- chitin binding
- Glyco_18 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chitotriosidase deficiency
- COVID-19
- colorectal cancer
- psoriasis
- primary pulmonary hypertension
- delayed hypersensitive reaction
- cutaneous sarcoidosis
- chronic obstructive pulmonary disease
- septic shock
- lepromatous leprosy
regulates
- chitin
- polysaccharide
role in cell
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- organelle lumens
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chit1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- immune response
- polysaccharide catabolic process
- chitin catabolic process
- polysaccharide digestion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- specific granule lumen
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- chitinase activity
- chitin binding
- hydrolase activity, hydrolyzing O-glycosyl compounds
- endochitinase activity