Rpl11 Gene Summary [Mouse]
A structural constituent of ribosome. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of signal transduction by p53 class mediator; and protein localization to nucleus. Located in cytoplasm and nucleolus. Part of cytosolic large ribosomal subunit. Is expressed in cerebral cortex. Used to study Diamond-Blackfan anemia 7. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 7 and T-cell acute lymphoblastic leukemia. Orthologous to human RPL11 (ribosomal protein L11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rpl11 |
| Official Name | ribosomal protein L11 [Source:MGI Symbol;Acc:MGI:1914275] |
| Ensembl ID | ENSMUSG00000059291 |
| Bio databases IDs | |
| Aliases | ribosomal protein L11 |
| Synonyms | 2010203J19RIK, DBA7, GIG34, L11, ribosomal protein L11, uL5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- structural constituent of ribosome
- peroxisome proliferator activated receptor binding
- ribosomal L5P family C-terminus
- 5S rRNA binding
- enzyme inhibitor activity
- Ribosomal protein L5
- protein binding
- enzyme regulator activity
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- Diamond-Blackfan anemia
- diamond-blackfan anemia type 7
- rheumatoid arthritis
- Alzheimer disease
- ovarian cancer
- acute myeloid leukemia
role in cell
- activation in
- expression in
- recruitment in
- accumulation in
- proliferation
- cell cycle progression
- cell death
- binding in
- differentiation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- multicilium
- nucleolar region
- ribosome
- cytosol
- nucleoplasm
- nucleoli
- synapse
- free polysome fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein binding
- cytoplasmic translation
- rRNA processing
- ribosomal large subunit assembly
- translation
- protein targeting
- positive regulation of gene expression
- ribosomal large subunit biogenesis
- protein stabilization
- protein localization to nucleus
- negative regulation of protein neddylation
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- macromolecular complex
- cytosolic large ribosomal subunit
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- ubiquitin protein ligase binding
- structural constituent of ribosome
- 5S rRNA binding