Uba6 Gene Summary [Mouse]
Enables FAT10 activating enzyme activity and ubiquitin activating enzyme activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including dendritic spine development; learning; and limbic system development. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebral cortex and gonad. Orthologous to human UBA6 (ubiquitin like modifier activating enzyme 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uba6 |
| Official Name | ubiquitin-like modifier activating enzyme 6 [Source:MGI Symbol;Acc:MGI:1913894] |
| Ensembl ID | ENSMUSG00000035898 |
| Bio databases IDs | |
| Aliases | ubiquitin-like modifier activating enzyme 6 |
| Synonyms | 4930542H01, 5730469D23Rik, E1-L2, FLJ10808, MOP-4, RGD1308324, UBE1L2, ubiquitin-like modifier activating enzyme 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uba6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-activating enzyme E1 FCCH domain
- Ubiquitin-activating enzyme E1 four-helix bundle
- ubiquitin activating enzyme
- ThiF family
- FAT10 activating enzyme
- enzyme
- protein binding
- ubiquitin-activating enzyme E1
- Ubiquitin-activating enzyme, SCCH domain
- E1_enzyme_family
- Ubiquitin fold domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uba6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory behavior
- amygdala development
- hippocampus development
- learning
- dendritic spine development
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- nucleotidyltransferase activity
- protein binding
- FAT10 activating enzyme activity
- ubiquitin activating enzyme activity
- thiosulfate sulfurtransferase activity