Ly75 Gene Summary [Mouse]
Predicted to enable signaling receptor activity. Predicted to be involved in endocytosis. Located in external side of plasma membrane. Is expressed in liver; thymus; and thymus primordium. Orthologous to several human genes including LY75 (lymphocyte antigen 75). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ly75 |
| Official Name | lymphocyte antigen 75 [Source:MGI Symbol;Acc:MGI:106662] |
| Ensembl ID | ENSMUSG00000026980 |
| Bio databases IDs | |
| Aliases | lymphocyte antigen 75 |
| Synonyms | CD205, CLEC13B, DEC-205, GP200-MR6, Lymphocyte antigen 75, Nldc145, RGD1565962 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ly75 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- beta-trefoil_Ricin_MRC-like
- protein binding
- cytosolic tail domain
- FN2
- transmembrane receptor
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Ly75 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- Alzheimer disease
- insomnia
- major depression
- eosinophilic esophagitis
- vascular dementia
- metabolic syndrome X
- Crohn disease
- early missed abortion
role in cell
- proliferation
- function
- abnormal morphology
- phagocytosis
- endocytosis by
- ricin resistance
- tolerance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- cell surface
- cellular membrane
- lysosome
- granules
- plasma membrane extracellular face
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ly75 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- immune response
- endocytosis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- signaling receptor activity
- carbohydrate binding