Lamp5 Gene Summary [Mouse]
Involved in presynaptic modulation of chemical synaptic transmission. Located in several cellular components, including dendrite membrane; endosome; and growth cone membrane. Is active in GABA-ergic synapse and synaptic vesicle. Is expressed in several structures, including alimentary system; central nervous system; sensory organ; vertebral axis musculature; and vibrissa. Orthologous to human LAMP5 (lysosomal associated membrane protein family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lamp5 |
| Official Name | lysosomal-associated membrane protein family, member 5 [Source:MGI Symbol;Acc:MGI:1923411] |
| Ensembl ID | ENSMUSG00000027270 |
| Bio databases IDs | |
| Aliases | lysosomal-associated membrane protein family, member 5 |
| Synonyms | 3110035N03Rik, 6330527O06Rik, BAD-LAMP, C20orf103, lysosomal associated membrane protein family member 5, lysosomal-associated membrane protein family, member 5, RGD1306991, UNC-46 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lamp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysosome-associated membrane glycoprotein (Lamp)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- cellular membrane
- Plasma Membrane
- lysosome
- ER-to-Golgi intermediate compartment
- endosomal membrane
- synaptic vesicles
- growth cone
- synapse
- late endosomes
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lamp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization to organelle
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- dendrite membrane
- late endosome membrane
- cytoplasmic vesicle membrane
- growth cone membrane
- endosome membrane
- recycling endosome membrane
- synaptic vesicle membrane
- lysosomal membrane
- plasma membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane