Zc3h8 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; liver; and spleen. Orthologous to human ZC3H8 (zinc finger CCCH-type containing 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zc3h8 |
| Official Name | zinc finger CCCH type containing 8 [Source:MGI Symbol;Acc:MGI:1930128] |
| Ensembl ID | ENSMUSG00000027387 |
| Bio databases IDs | |
| Aliases | zinc finger CCCH type containing 8 |
| Synonyms | E130108N08Rik, FLIZ1, ZC3HDC8, zinc finger CCCH-type containing 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zc3h8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- CCCH-type zinc finger
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- zinc finger domain
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
- Cajal bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zc3h8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell differentiation in thymus
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- apoptotic process
- response to antibiotic
- positive regulation of thymocyte apoptotic process
- snRNA transcription from RNA polymerase II promoter
- snRNA transcription from RNA polymerase III promoter
- positive regulation of transcription from RNA polymerase III promoter
- T cell homeostasis
Cellular Component
Where in the cell the gene product is active
- histone locus body
- nucleus
- euchromatin
- nuclear body
- transcription elongation factor complex
- Cajal body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- metal ion binding
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription