Zcrb1 Gene Summary [Mouse]
Predicted to enable RNA binding activity and zinc ion binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U12-type spliceosomal complex. Is expressed in central nervous system and sensory organ. Orthologous to human ZCRB1 (zinc finger CCHC-type and RNA binding motif containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zcrb1 |
| Official Name | zinc finger CCHC-type and RNA binding motif 1 [Source:MGI Symbol;Acc:MGI:1914447] |
| Ensembl ID | ENSMUSG00000022635 |
| Bio databases IDs | |
| Aliases | zinc finger CCHC-type and RNA binding motif 1 |
| Synonyms | 2700088M22Rik, MADP-1, RBM36, RGD1309851, SNRNP31, ZCCHC19, zinc finger CCHC-type and RNA binding motif 1, zinc finger CCHC-type and RNA binding motif containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zcrb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc knuckle
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
Pathways
Biological processes and signaling networks where the Zcrb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- immunodeficiency
- high grade glioma
- glioma cancer
- glioma formation
- low-grade glioma
- systemic juvenile idiopathic arthritis
role in cell
- replication in
- proliferation
- formation in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zcrb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- U12-type spliceosomal complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA binding