Lin28b Gene Summary [Mouse]
Predicted to enable mRNA binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in RNA metabolic process and positive regulation of macromolecule metabolic process. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and lumbar dorsal root ganglion. Used to study neuroblastoma. Orthologous to human LIN28B (lin-28 homolog B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lin28b |
| Official Name | lin-28 homolog B (C. elegans) [Source:MGI Symbol;Acc:MGI:3584032] |
| Ensembl ID | ENSMUSG00000063804 |
| Bio databases IDs | |
| Aliases | lin-28 homolog B (C. elegans) |
| Synonyms | 2810403D23Rik, CSDD2, D030047M17Rik, Lin-28.2, lin-28 homolog B, LOC683611 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lin28b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S1_like
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- Cold shock protein domain
- RNA binding
Pathways
Biological processes and signaling networks where the Lin28b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- metastasis
- neoplasia
- weight loss
- colorectal cancer
- tumorigenesis
- schizophrenia
- growth failure
role in cell
- activation in
- proliferation
- expression in
- loss
- growth
- phosphorylation in
- migration
- differentiation
- invasion by
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lin28b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of primary miRNA processing
- pre-miRNA processing
- positive regulation of miRNA catabolic process
- RNA 3'-end processing
- negative regulation of pre-miRNA processing
- RNA destabilization
- miRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA binding
- mRNA binding