Defb22 Gene Summary [Mouse]
Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and defense response to Gram-negative bacterium. Located in cell surface and sperm glycocalyx. Orthologous to human DEFB126 (defensin beta 126). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Defb22 |
| Official Name | defensin beta 22 [Source:MGI Symbol;Acc:MGI:3045368] |
| Ensembl ID | ENSMUSG00000027468 |
| Bio databases IDs | |
| Aliases | defensin beta 22 |
| Synonyms | 2D6glycoprotein, 9230002F21Rik, bA530N10.1, C20orf8, Defb22, DEFB-26, defensin beta 126, defensin beta 22, defensin β 126, defensin β 22, HBD26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Defb22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta defensin
Pathways
Biological processes and signaling networks where the Defb22 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- glycocalyx
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Defb22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to Gram-negative bacterium
- single fertilization
Cellular Component
Where in the cell the gene product is active
- extracellular region