Car1 Gene Summary [Mouse]

Predicted to enable arylesterase activity; carbonate dehydratase activity; and cyanamide hydratase activity. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and skeleton. Used to study major depressive disorder. Human ortholog(s) of this gene implicated in autoimmune disease (multiple) and viral hepatitis. Orthologous to human CA1 (carbonic anhydrase 1). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Car1
Official Name
carbonic anhydrase 1 [Source:MGI Symbol;Acc:MGI:88268]
Ensembl ID
ENSMUSG00000027556
Bio databases IDs NCBI: 12346 Ensembl: ENSMUSG00000027556
Aliases carbonic anhydrase 1
Synonyms CAB, CA-I, Car1, Carbonic Anhydrase, Carbonic anhydrase 1, HEL-S-11, LOC679649
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Car1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • carbonate dehydratase
  • hydro-lyase
  • Eukaryotic-type carbonic anhydrase
  • alpha_CA
  • enzyme
  • protein binding
  • arylesterase
  • DNA (cytosine-5-)-methyltransferase
  • cyanamide hydratase

Pathways

Biological processes and signaling networks where the Car1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • SREBF1
  • PDZD8
  • TFCP2
  • acetazolamide
  • quinethazone
  • hydrochlorothiazide
  • diazoxide
  • sulfacetamide
  • dichlorphenamide
  • topiramate
regulates
regulated by
  • celecoxib
  • CDX2
  • methazolamide
  • valdecoxib
  • morphine
  • ethoxyzolamide
  • EPO
  • acetazolamide
  • CA1
  • L-glutamic acid
disease
  • anxiety disorder
  • schizophrenia
  • obstructive sleep apnea
  • dementia
  • depressive disorder
  • vomiting
  • myocardial infarction
  • stroke
  • edema
  • headache
role in cell
  • homeostasis
  • calcification

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • cytosol
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Car1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • one-carbon metabolic process

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • zinc ion binding
  • protein binding
  • hydro-lyase activity
  • arylesterase activity
  • carbonate dehydratase activity
  • cyanamide hydratase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.