Tfcp2 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human TFCP2 (transcription factor CP2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfcp2 |
| Official Name | transcription factor CP2 [Source:MGI Symbol;Acc:MGI:98509] |
| Ensembl ID | ENSMUSG00000009733 |
| Bio databases IDs | |
| Aliases | transcription factor CP2 |
| Synonyms | alpha CP2, Alpha-globin transcription factor cp2, CP-2, CP2c, D230015P20RIK, LBP1, LBP-1c, LBP-1d, LSF, LSF1D, SEF, Tcfcp2, TFCP2C, transcription factor CP2, UBP-1, α CP2, α-globin transcription factor cp2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tfcp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- dimerization domain
- DNA binding domain
- nucleic acid binding
- Q/P domain
- SAM (Sterile alpha motif )
- C-terminal acidic domain
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- SAM domain (Sterile alpha motif)
- SPXX domain
- extreme N-terminal domain
- SAM like-domain
- basic domain
- transcription factor activity
- CP2 transcription factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- hepatocellular carcinoma
- tumorigenesis
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- liver cancer
- Alzheimer disease
- psoriasis
role in cell
- expression in
- cell death
- activation in
- cell cycle progression
- growth
- apoptosis
- proliferation
- formation
- formation in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tfcp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription factor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity