Car1 Gene Summary [Rat]
Predicted to enable arylesterase activity; carbonate dehydratase activity; and cyanamide hydratase activity. Involved in response to fructose. Predicted to be active in cytoplasm. Biomarker of colitis. Human ortholog(s) of this gene implicated in autoimmune disease (multiple) and viral hepatitis. Orthologous to human CA1 (carbonic anhydrase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Car1 |
| Official Name | carbonic anhydrase 1 [Source:RGD Symbol;Acc:1309780] |
| Ensembl ID | ENSRNOG00000010698 |
| Bio databases IDs | |
| Aliases | carbonic anhydrase 1 |
| Synonyms | CAB, CA-I, Car1, Carbonic Anhydrase, Carbonic anhydrase 1, HEL-S-11, LOC679649 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Car1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carbonate dehydratase
- hydro-lyase
- Eukaryotic-type carbonic anhydrase
- alpha_CA
- enzyme
- protein binding
- arylesterase
- DNA (cytosine-5-)-methyltransferase
- cyanamide hydratase
Pathways
Biological processes and signaling networks where the Car1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- bicarbonate
- CA1
- ALDH1A2
disease
- anxiety disorder
- schizophrenia
- obstructive sleep apnea
- dementia
- depressive disorder
- vomiting
- myocardial infarction
- stroke
- edema
- headache
role in cell
- homeostasis
- calcification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Car1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- hydro-lyase activity
- arylesterase activity
- carbonate dehydratase activity
- cyanamide hydratase activity