Aldh1a2 Gene Summary [Mouse]
Enables 3-chloroallyl aldehyde dehydrogenase activity and retinal dehydrogenase activity. Involved in cellular response to retinoic acid. Acts upstream of or within several processes, including circulatory system development; nervous system development; and retinoid metabolic process. Predicted to be located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study DiGeorge syndrome. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh1a2 |
| Official Name | aldehyde dehydrogenase family 1, subfamily A2 [Source:MGI Symbol;Acc:MGI:107928] |
| Ensembl ID | ENSMUSG00000013584 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase family 1, subfamily A2 |
| Synonyms | aldehyde dehydrogenase 1 family member A2, aldehyde dehydrogenase 1 family, member A2, aldehyde dehydrogenase family 1, subfamily A2, Aldh1a7, AV116159, DIH4, Raldh1, RALDH2, RALDH2-T, RALDH(II), RETINALDEHYDE DEHYDROGENASE 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aldh1a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
- betaine-aldehyde dehydrogenase
- aldehyde dehydrogenase (NAD)
- retinal dehydrogenase
- aldehyde dehydrogenase
- retinal binding
- enzyme
- methylmalonic acid semialdehyde dehydrogenase
- 2-hydroxymuconic semialdehyde dehydrogenase
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the Aldh1a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- stroke
- age-related macular degeneration
- COVID-19
- non-insulin-dependent diabetes mellitus
- hypoplasia
- amyotrophic lateral sclerosis
- metabolic syndrome X
- Barrett syndrome
- idiopathic scoliosis
phenotypes
- aberrant origin of the right subclavian artery
- abnormal aortic arch and aortic arch branch attachment
- abnormal artery morphology
- abnormal common carotid artery morphology
- abnormal cranial nerve morphology
- abnormal cricoid cartilage morphology
- abnormal embryo turning
- abnormal embryonic tissue morphology
- abnormal fetal atrioventricular canal morphology
- abnormal fetal cardiomyocyte morphology
- abnormal first pharyngeal arch morphology
- abnormal glossopharyngeal ganglion morphology
- abnormal heart development
- abnormal heart tube morphology
- abnormal laryngeal cartilage morphology
- abnormal left subclavian artery morphology
- abnormal mandibular prominence morphology
- abnormal maxillary prominence morphology
- abnormal myocardium layer morphology
- abnormal nervous system development
- abnormal neural crest cell migration
- abnormal neural tube morphology
- abnormal otic vesicle morphology
- abnormal pharyngeal arch artery morphology
- abnormal pharyngeal arch morphology
- abnormal pharyngeal pouch morphology
- abnormal somite development
- abnormal third pharyngeal arch artery morphology
- abnormal thyroid cartilage morphology
- abnormal tracheal cartilage morphology
- abnormal trigeminal ganglion morphology
- abnormal truncus arteriosus septation
- abnormal vagus ganglion morphology
- abnormal vascular development
- abnormal vestibulocochlear ganglion morphology
- abnormal vitamin A metabolism
- abnormal vitelline vasculature morphology
- absent Wolffian ducts
- absent atrioventricular cushions
- absent forelimb buds
- absent fourth pharyngeal arch
- absent hindlimb buds
- absent myocardial trabeculae
- absent parathyroid glands
- absent pharyngeal arch arteries
- absent pharyngeal arches
- absent second pharyngeal arch
- absent third pharyngeal arch
- athymia
- caudal body truncation
- cervical aortic arch
- conotruncal ridge hypoplasia
- cyanosis
- decreased body length
- decreased body size
- decreased embryo size
- decreased somite size
- decreased tracheal cartilage ring number
- double aortic arch
- embryonic growth arrest
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality complete penetrance
- enlarged heart
- failure of heart looping
- failure of ventral body wall closure
- fusion of glossopharyngeal and vagus nerve
- incomplete caudal neuropore closure
- no abnormal phenotype detected
- otic vesicle hypoplasia
- persistent truncus arteriosis
- pharyngeal arch hypoplasia
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- renal hypoplasia
- right aortic arch
- short trachea
- small first pharyngeal arch
- small forelimb buds
- small frontonasal prominence
- small otic vesicle
- thick myocardium
- thymus hypoplasia
- ventricular septal defect
role in cell
- growth
- expression in
- proliferation
- differentiation
- quantity
- apoptosis
- number
- abnormal morphology
- development
- distribution
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aldh1a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- neural tube development
- cell proliferation
- midgut development
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- retinol metabolic process
- retinoic acid metabolic process
- retinal metabolic process
- cardiac muscle tissue development
- face development
- proximal/distal pattern formation
- determination of bilateral symmetry
- response to retinoic acid
- heart morphogenesis
- retinoic acid biosynthetic process
- protein homotetramerization
- blood vessel development
- embryonic digestive tract development
- hindbrain development
- kidney development
- liver development
- morphogenesis of embryonic epithelium
- embryonic forelimb morphogenesis
- ureter maturation
- lung development
- pancreas development
- neural crest cell development
- 9-cis-retinoic acid biosynthetic process
- embryonic camera-type eye development
- neuron differentiation
- vitamin A metabolic process
- pituitary gland development
- cellular response to retinoic acid
- positive regulation of gene expression
- positive regulation of apoptotic process
- response to estradiol stimulus
- response to vitamin A
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- 3-chloroallyl aldehyde dehydrogenase activity
- retinal dehydrogenase activity
- retinal binding