4933434E20Rik Gene Summary [Mouse]
Involved in phagocytosis. Acts upstream of or within in utero embryonic development. Predicted to be located in Golgi apparatus; cytosol; and mitochondrion. Orthologous to human C1orf43 (chromosome 1 open reading frame 43). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | 4933434E20Rik |
| Official Name | RIKEN cDNA 4933434E20 gene [Source:MGI Symbol;Acc:MGI:1914027] |
| Ensembl ID | ENSMUSG00000027942 |
| Bio databases IDs | |
| Aliases | RIKEN cDNA 4933434E20 gene |
| Synonyms | 4933434E20Rik, 5730552F22Rik, AC163616.1, chromosome 1 open reading frame 43, HSPC012, NICE-3, NS5ATP4, NS5A transactivated protein 4, RIKEN cDNA 4933434E20 gene, S863-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse 4933434e20rik often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NICE-3 protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
phenotypes
- decreased circulating HDL cholesterol level
- decreased circulating cholesterol level
- decreased circulating fructosamine level
- decreased circulating serum albumin level
- decreased circulating triglyceride level
- decreased total body fat amount
- increased bone mineral content
- increased bone mineral density
- increased food intake
- preweaning lethality complete penetrance
- abnormal Mullerian duct morphology
- abnormal Wolffian duct connection
- abnormal aortic valve cusp morphology
- abnormal atrioventricular cushion morphology
- abnormal brain internal capsule morphology
- abnormal cerebral cortex morphology
- abnormal ductus venosus valve morphology
- abnormal ductus venosus valve topology
- abnormal dural venous sinus morphology
- abnormal eye muscle morphology
- abnormal forebrain morphology
- abnormal heart atrium morphology
- abnormal heart position or orientation
- abnormal heart right atrium morphology
- abnormal hindbrain morphology
- abnormal hypoglossal nerve topology
- abnormal inferior vena cava valve morphology
- abnormal infrahyoid muscle connection
- abnormal interatrial septum morphology
- abnormal larynx morphology
- abnormal lens morphology
- abnormal pectinate muscle morphology
- abnormal pineal gland morphology
- abnormal pulmonary valve cusp morphology
- abnormal vertebral arch morphology
- abnormal vertebral artery topology
- abnormal vertebral body morphology
- abnormal vitelline vein connection
- absent costovertebral joint
- absent ductus venosus valve
- absent hypoglossal canal
- absent hypoglossal nerve
- absent lobe of thyroid gland
- absent segment of posterior cerebral artery
- absent vertebral arch
- anal atresia
- arteriovenous malformation
- blood in lymph vessels
- dorsal root ganglion hypoplasia
- double ureter
- embryo cyst
- enlarged liver sinusoidal spaces
- enlarged lymphatic vessel
- fused dorsal root ganglion
- fusion of vertebral arches
- herniated liver
- heterochrony
- intestinal/bowel diverticulum
- muscular ventricular septal defect
- overriding aortic valve
- perimembraneous ventricular septal defect
- persistent trigeminal artery
- reduced sympathetic cervical ganglion size
- retro-esophageal left subclavian artery
- retroesophageal right subclavian artery
- right aortic arch
- small superior cervical ganglion
- subcutaneous edema
- thin hypoglossal nerve
- urinary bladder hypoplasia
role in cell
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Golgi Apparatus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse 4933434e20rik gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- phagocytosis
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrion
- cytosol
- Golgi apparatus