Lrrtm1 Gene Summary [Mouse]
Acts upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Predicted to be located in several cellular components, including endoplasmic reticulum; excitatory synapse; and growth cone. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Is expressed in several structures, including central nervous system; future brain; limb; peripheral nervous system; and sensory organ. Used to study schizophrenia. Orthologous to human LRRTM1 (leucine rich repeat transmembrane neuronal 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrtm1 |
| Official Name | leucine rich repeat transmembrane neuronal 1 [Source:MGI Symbol;Acc:MGI:2389173] |
| Ensembl ID | ENSMUSG00000060780 |
| Bio databases IDs | |
| Aliases | leucine rich repeat transmembrane neuronal 1 |
| Synonyms | 4632401D06Rik, leucine rich repeat transmembrane neuronal 1, LOC684054, Lrrtm2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrtm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- Endoplasmic Reticulum
- postsynaptic membrane
- synaptic membrane
- growth cone
- synapse
- axons
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrtm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exploration behavior
- locomotory behavior
- negative regulation of receptor internalization
- synapse organization
- long-term synaptic potentiation
- protein localization to synapse
- establishment of localization in cell
- positive regulation of synapse assembly
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- growth cone
- extracellular space
- excitatory synapse
- endoplasmic reticulum
- extracellular matrix
- axon
- cell surface