Kcnq5 Gene Summary [Mouse]
Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of clathrin coat and voltage-gated potassium channel complex. Predicted to be active in calyx of Held and presynaptic membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 46. Orthologous to human KCNQ5 (potassium voltage-gated channel subfamily Q member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnq5 |
| Official Name | potassium voltage-gated channel, subfamily Q, member 5 [Source:MGI Symbol;Acc:MGI:1924937] |
| Ensembl ID | ENSMUSG00000028033 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, subfamily Q, member 5 |
| Synonyms | 7730402H11, 9230107O05Rik, AL365232.1, D1Mgi1, Kcnq5l, Kv7.5, LOC689123, MRD46, potassium voltage-gated channel subfamily Q member 5, potassium voltage-gated channel, subfamily Q, member 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnq5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KCNQ voltage-gated potassium channel
- voltage-gated potassium channel
- Ion transport protein
- protein binding
- voltage-gated ion channel
- ion channel
- Polycystin cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proliferative diabetic retinopathy
- insomnia
- major depression
- myopia
- hereditary disorder
- hyperopia
- autosomal dominant mental retardation type 46
- schizophrenia
- primary angle-closure glaucoma
- metabolic syndrome X
regulates
- K+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- presynaptic membrane
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnq5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- clathrin coat
- voltage-gated potassium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding