Chrm1 Gene Summary [Mouse]
Predicted to enable G protein-coupled acetylcholine receptor activity. Involved in postsynaptic modulation of chemical synaptic transmission and regulation of postsynaptic membrane potential. Acts upstream of or within regulation of locomotion. Is active in Schaffer collateral - CA1 synapse; cholinergic synapse; and postsynaptic membrane. Is expressed in central nervous system; exocrine system; retina; and urinary system. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrm1 |
| Official Name | cholinergic receptor, muscarinic 1, CNS [Source:MGI Symbol;Acc:MGI:88396] |
| Ensembl ID | ENSMUSG00000032773 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, muscarinic 1, CNS |
| Synonyms | Achr, cholinergic receptor muscarinic 1, cholinergic receptor, muscarinic 1, cholinergic receptor, muscarinic 1, CNS, HM1, M1, M1 MUSCARINIC receptor, M1R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled acetylcholine receptor
- intracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- ion channel
Pathways
Biological processes and signaling networks where the Chrm1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- cancer
- migraines
- nausea
- headache
- acute mountain sickness
- vomiting
- postoperative nausea and vomiting
- chemotherapy sickness
- psychosis
role in cell
- proliferation
- apoptosis
- activation in
- mitochondrial respiration in
- formation
- molecular cleavage in
- ruffling
- phosphorylation in
- activation
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- neurites
- synapse
- perikaryon
- dendrites
- axon terminals
- postsynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- regulation of postsynaptic membrane potential
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway
- regulation of locomotion
- neuromuscular synaptic transmission
- signal transduction
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- regulation of glial cell proliferation
- nervous system development
- G-protein coupled acetylcholine receptor signaling pathway
- synaptic transmission
- protein kinase C-activating G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
- positive regulation of ion transport
- cognition
- saliva secretion
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- membrane
- synapse
- plasma membrane
- axon terminus
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity