Mcoln3 Gene Summary [Mouse]
Enables monoatomic anion channel activity; potassium channel activity; and sodium channel activity. Acts upstream of or within inner ear auditory receptor cell differentiation; locomotory behavior; and sensory perception of sound. Located in cytoplasm and plasma membrane. Is expressed in cochlea; olfactory epithelium; and vibrissa. Orthologous to human MCOLN3 (mucolipin TRP cation channel 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcoln3 |
| Official Name | mucolipin 3 [Source:MGI Symbol;Acc:MGI:1890500] |
| Ensembl ID | ENSMUSG00000036853 |
| Bio databases IDs | |
| Aliases | mucolipin 3 |
| Synonyms | 6720490O21Rik, mucolipin 3, mucolipin TRP cation channel 3, TRP-ML3, Va |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcoln3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- sodium channel
- anion channel
- ELD_TRPML
- Ion transport protein
- calcium channel
- transmembrane domain
- loop domain
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- breast adenocarcinoma
- hearing loss
role in cell
- apoptosis
- cell viability
- cell death
- loss
- degradation in
- accumulation in
- differentiation
- maturation
- development
- bundling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- inner hair cell bundle
- Cytoplasm
- cellular membrane
- vesicles
- lysosome
- Endoplasmic Reticulum
- granules
- early endosomes
- late endosomes
- autophagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcoln3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory behavior
- potassium ion transmembrane transport
- auditory receptor cell differentiation
- calcium ion transmembrane transport
- sodium ion transmembrane transport
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- autophagic vacuole membrane
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- NAADP-sensitive calcium-release channel activity
- calcium channel activity
- sodium channel activity
- anion channel activity
- lipid binding
- potassium channel activity