Kcns3 Gene Summary [Mouse]
Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in dentate gyrus subgranular zone and otocyst. Orthologous to human KCNS3 (potassium voltage-gated channel modifier subfamily S member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcns3 |
| Official Name | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 [Source:MGI Symbol;Acc:MGI:1098804] |
| Ensembl ID | ENSMUSG00000043673 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 |
| Synonyms | KV9.3, potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3, potassium voltage-gated channel modifier subfamily S member 3, potassium voltage-gated channel, modifier subfamily S, member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcns3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- delayed rectifier potassium channel
- Ion transport protein
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- potassium channel regulator
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- conotruncal heart malformations
- coronary artery disease
- breast carcinoma
- Parkinson disease
- colorectal cancer
- pervasive developmental disorder
- idiopathic scoliosis
- cleft lip
- chronic obstructive pulmonary disease
- prostate cancer
regulates
- K+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcns3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- protein homooligomerization
- regulation of action potential
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- membrane
- cytosol
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- delayed rectifier potassium channel activity
- potassium channel regulator activity