Manba Gene Summary [Mouse]
Enables beta-mannosidase activity. Involved in glycoprotein catabolic process and oligosaccharide catabolic process. Located in extracellular space. Is active in lysosomal lumen. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and heart. Used to study beta-mannosidosis. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Manba |
| Official Name | mannosidase, beta A, lysosomal [Source:MGI Symbol;Acc:MGI:88175] |
| Ensembl ID | ENSMUSG00000028164 |
| Bio databases IDs | |
| Aliases | mannosidase, beta A, lysosomal |
| Synonyms | 2410030O07Rik, B930014J03Rik, Beta-mannosidase, BMAN, Bmn, MANB1, mannosidase beta, mannosidase, beta A, lysosomal, mannosidase β, mannosidase, β A, lysosomal, β-mannosidase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Manba often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-mannosidase
- Glycosyl hydrolases family 2, sugar binding domain
- enzyme
- hydrolase
- Mannosidase Ig/CBM-like domain
- Ig-fold domain
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- beta-mannosidosis
- headache
- primary biliary cirrhosis
- substance-related disorder
- asthma
- attention deficit hyperactivity disorder
- sarcoidosis
- systemic lupus erythematosus
- multiple sclerosis
- pervasive developmental disorder
regulates
- glycoprotein
- oligosaccharide
role in cell
- abnormal morphology
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Extracellular Space
- Plasma Membrane
- lysosome
- secretory granule membrane
- lysosome membrane
- lysosomal compartment
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Manba gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein catabolic process
- protein modification process
- oligosaccharide catabolic process
Cellular Component
Where in the cell the gene product is active
- lysosomal lumen
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- beta-mannosidase activity
- mannose binding