Ak4 Gene Summary [Mouse]
Predicted to enable adenylate kinase activity; nucleoside diphosphate kinase activity; and nucleoside triphosphate adenylate kinase activity. Predicted to be involved in nucleoside phosphate metabolic process and regulation of oxidative phosphorylation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including AK4 (adenylate kinase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ak4 |
| Official Name | adenylate kinase 4 [Source:MGI Symbol;Acc:MGI:87979] |
| Ensembl ID | ENSMUSG00000028527 |
| Bio databases IDs | |
| Aliases | adenylate kinase 4 |
| Synonyms | adenylate kinase 4, AK3, Ak3l, AK3L1, AK3L2, D4Ertd274e, gtp:amp phosphotransferase, mitochondrial |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ak4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleoside diphosphate kinase
- adenylate kinase
- nucleoside-phosphate kinase
- NK
- adenylate kinase, isozyme 1 subfamily
- UMP-CMP kinase family
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein binding
- nucleoside-triphosphate-adenylate kinase
- AAA domain
- Adenylate kinase, active site lid
Pathways
Biological processes and signaling networks where the Ak4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- non-insulin-dependent diabetes mellitus
- organismal death
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- schizophrenia
- adult T cell leukemia
- primary pulmonary hypertension
regulates
- guanosine triphosphate
- AKT
- adenosine triphosphate
- HIF1A
- 16:0/20:4(5Z,8Z,11Z,14Z) phosphatidylethanolamine
- 8-hydroxy-9,10-epoxystearic acid
- d18:1/16:1(9Z)(OH) sphingomyelin
- choline
- lactic acid
- 8-amino-7-oxononanoic acid
role in cell
- phosphorylation in
- production in
- growth
- expression in
- proliferation
- migration
- cell viability
- response by
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ak4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribonucleoside diphosphate biosynthetic process
- regulation of oxidative phosphorylation
- AMP metabolic process
- ADP biosynthetic process
- nucleobase-containing small molecule interconversion
- nucleoside triphosphate biosynthetic process
- ATP metabolic process
- GTP metabolic process
- nucleoside monophosphate phosphorylation
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- GTP binding
- nucleoside phosphate kinase activity
- adenylate kinase activity
- ATP binding
- protein binding
- nucleoside diphosphate kinase activity
- nucleoside triphosphate adenylate kinase activity