Trub2 Gene Summary [Mouse]
Predicted to enable pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and positive regulation of mitochondrial translation. Predicted to be located in mitochondrion and ribonucleoprotein granule. Is expressed in trunk unsegmented mesenchyme. Orthologous to human TRUB2 (TruB pseudouridine synthase family member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trub2 |
| Official Name | TruB pseudouridine (psi) synthase family member 2 [Source:MGI Symbol;Acc:MGI:2442186] |
| Ensembl ID | ENSMUSG00000039826 |
| Bio databases IDs | |
| Aliases | TruB pseudouridine (psi) synthase family member 2 |
| Synonyms | CLONE24922, G430055L02RIK, LOC685694, TruB pseudouridine (psi) synthase family member 2, TruB pseudouridine synthase family member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trub2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TruB family pseudouridylate synthase (N terminal domain)
- PseudoU_synth
- pseudouridine synthase
- enzyme
- tRNA pseudouridylate synthase B C-terminal domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribonucleoprotein granule
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trub2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
- positive regulation of mitochondrial translation
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- ribonucleoprotein granule
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- RNA binding
- pseudouridine synthase activity