Gtpbp3 Gene Summary [Mouse]
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gtpbp3 |
| Official Name | GTP binding protein 3 [Source:MGI Symbol;Acc:MGI:1917609] |
| Ensembl ID | ENSMUSG00000007610 |
| Bio databases IDs | |
| Aliases | GTP binding protein 3 |
| Synonyms | 2410009F13Rik, AI607903, COXPD23, GTPBG3, GTP binding protein 3, GTP binding protein 3, mitochondrial, LOC108167534, MSS1, MTGP1, THDF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gtpbp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- MnmE helical domain
- tRNA modification GTPase TrmE
- transferase
- GTP-binding protein TrmE N-terminus
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gtpbp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA wobble uridine modification
- tRNA methylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity