Pla2g2c Gene Summary [Mouse]

Predicted to enable several functions, including calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in phosphatidylcholine metabolic process and phosphatidylglycerol metabolic process. Predicted to act upstream of or within phospholipid catabolic process. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human PLA2G2C (phospholipase A2 group IIC). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Pla2g2c
Official Name
phospholipase A2, group IIC [Source:MGI Symbol;Acc:MGI:106638]
Ensembl ID
ENSMUSG00000028750
Bio databases IDs NCBI: 18781 Ensembl: ENSMUSG00000028750
Aliases phospholipase A2, group IIC
Synonyms LOC105376824, phospholipase A2 group IIC, phospholipase A2, group IIC, UBXN10-AS1
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pla2g2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • calcium-dependent phospholipase A2
  • enzyme
  • phospholipase A2
  • PLA2_like

Pathways

Biological processes and signaling networks where the Pla2g2c gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • depressive disorder
regulates
  • phospholipid

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Pla2g2c gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • phosphatidylcholine metabolic process
  • arachidonic acid secretion
  • positive regulation of fibroblast proliferation
  • lipid catabolic process
  • fatty acid biosynthetic process
  • phospholipid metabolic process

Cellular Component

Where in the cell the gene product is active
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • calcium-dependent phospholipase A2 activity
  • calcium ion binding
  • phospholipid binding
  • receptor binding

Gene-Specific Assays for Results You Can Trust

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