Pla2g2c Gene Summary [Rat]
Enables calcium-dependent phospholipase A2 activity. Predicted to be involved in phosphatidylcholine metabolic process and phosphatidylglycerol metabolic process. Predicted to be located in extracellular region and membrane. Orthologous to human PLA2G2C (phospholipase A2 group IIC). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g2c |
| Official Name | phospholipase A2, group IIC [Source:RGD Symbol;Acc:3340] |
| Ensembl ID | ENSRNOG00000016647 |
| Bio databases IDs | |
| Aliases | phospholipase A2, group IIC |
| Synonyms | LOC105376824, phospholipase A2 group IIC, phospholipase A2, group IIC, UBXN10-AS1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pla2g2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent phospholipase A2
- enzyme
- phospholipase A2
- PLA2_like
Pathways
Biological processes and signaling networks where the Pla2g2c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- depressive disorder
regulates
- phospholipid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pla2g2c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylcholine metabolic process
- arachidonic acid secretion
- positive regulation of fibroblast proliferation
- lipid catabolic process
- fatty acid biosynthetic process
- phospholipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- phospholipid binding
- receptor binding