Fabp3 Gene Summary [Mouse]
Predicted to enable cytoskeletal protein binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including cholesterol homeostasis; phospholipid homeostasis; and positive regulation of long-chain fatty acid import into cell. Acts upstream of or within brown fat cell differentiation and regulation of phosphatidylcholine biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human FABP3 (fatty acid binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fabp3 |
| Official Name | fatty acid binding protein 3, muscle and heart [Source:MGI Symbol;Acc:MGI:95476] |
| Ensembl ID | ENSMUSG00000028773 |
| Bio databases IDs | |
| Aliases | fatty acid binding protein 3, muscle and heart |
| Synonyms | FABP, FABP11, FABPc, Fabph-1, Fabph-4, fatty acid binding protein 3, fatty acid binding protein 3, muscle and heart, Heart fabp, Heart fatty acid binding, H-FABP, Kidney fabp, mammary-derived growth inhibitor, MDGI, M-FABP, O-FABP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fabp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain fatty acid transporter
- icosatetraenoic acid binding
- cytoskeletal protein binding
- lipocalin/cytosolic fatty acid-binding protein family
- fatty acid binding
- protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the Fabp3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- aldosterone producing adrenocortical adenoma
- stroke
- cardiac hypertrophy
- androgenic alopecia
- amyotrophic lateral sclerosis
- fatigue
- esophageal adenocarcinoma
- esophageal carcinoma formation
- Barrett syndrome
role in cell
- proliferation
- accumulation in
- expression in
- differentiation
- quantity
- survival
- degeneration
- upregulation in
- fractional shortening
- inflammation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- endosomes
- lysosome
- Mitochondria
- cytosol
- sarcoplasm
- neurites
- giant vesicles
- perikaryon
- axon terminals
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fabp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- brown fat cell differentiation
- positive regulation of phospholipid biosynthetic process
- long-chain fatty acid transport
- negative regulation of cell proliferation
- regulation of fatty acid oxidation
- intracellular lipid transport
- cholesterol homeostasis
- phospholipid homeostasis
- regulation of phosphatidylcholine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- long-chain fatty acid binding
- cytoskeletal protein binding
- oleic acid binding