Nup62 Gene Summary [Mouse]
Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and PTB domain binding activity. Involved in negative regulation of cell population proliferation and negative regulation of signal transduction. Acts upstream of or within cellular senescence. Located in nuclear membrane. Part of nuclear pore. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in primary biliary cholangitis and striatonigral degeneration. Orthologous to human NUP62 (nucleoporin 62). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup62 |
| Official Name | nucleoporin 62 [Source:MGI Symbol;Acc:MGI:1351500] |
| Ensembl ID | ENSMUSG00000109511 |
| Bio databases IDs | |
| Aliases | nucleoporin 62 |
| Synonyms | D7Ertd649e, IBSN, Np62, nucleoporin 62, Nupc1, p62, SNDI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nup62 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nsp1-like C-terminal region
- Hsp70 protein binding
- SH2-domain binding
- FXFG repeat
- heat shock protein binding
- ubiquitin binding
- coiled-coil domain
- protein domain specific binding
- protein binding
- thyroid hormone receptor binding
- kinesin binding
- CENP-Q, a CENPA-CAD centromere complex subunit
- FG repeat
- binding protein
- phenylalanine-glycine motif
- receptor signaling complex scaffold protein
- structural constituent of nuclear pore
- T-rich linker region
- Growth-arrest specific micro-tubule binding
- FG rich domain
- transporter
Pathways
Biological processes and signaling networks where the Nup62 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriatic arthritis
- major depression
- primary antiphospholipid antibody syndrome
- infantile striatonigral degeneration
- cervical squamous cell carcinoma
- squamous cell cervical cancer
- hearing loss
- colon carcinoma
- colon epithelial cancer
- stomatitis
role in cell
- replication in
- proliferation
- cell death
- expression in
- binding in
- activation in
- cell viability
- apoptosis
- binding
- simplification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear membrane fraction
- detergent resistant lipid raft fraction
- endomembrane system
- Cytoplasm
- perinuclear region
- centrosome
- Flemming body
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- spindle pole
- perichromosomal layer
- nuclear envelope
- Cajal bodies
- mitotic spindle
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nup62 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome cycle
- negative regulation of cell proliferation
- cellular senescence
- regulation of Ras protein signal transduction
- positive regulation of epidermal growth factor receptor signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of centriole replication
- mitotic centrosome separation
- cell surface receptor signaling pathway
- negative regulation of programmed cell death
- positive regulation of mitosis
- negative regulation of epidermal growth factor receptor signaling pathway
- regulation of mitotic spindle organization
- regulation of signal transduction
- nucleocytoplasmic transport
- RNA export from nucleus
- negative regulation of Ras protein signal transduction
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- protein import into nucleus
- mitotic metaphase plate congression
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- centrosome
- mitotic spindle
- cytoplasm
- spindle pole
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- structural constituent of nuclear pore
- Hsp90 protein binding
- chromatin binding
- SH2 domain binding
- phospholipid binding
- PTB domain binding
- Hsp70 protein binding
- receptor signaling complex scaffold activity