Itga11

Predicted to enable collagen binding activity involved in cell-matrix adhesion; collagen receptor activity; and integrin binding activity. Acts upstream of or within fibroblast migration and substrate-dependent cell migration. Predicted to be located in focal adhesion. Predicted to be part of integrin alpha11-beta1 complex. Predicted to be active in external side of plasma membrane. Is expressed in brain meninges; limb; skeleton; tail paraxial mesenchyme; and thymus primordium. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ITGA11 (integrin subunit alpha 11). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itga11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Itga11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Itga11 gene, providing context for its role in the cell.