Cdkn1b Gene Summary [Mouse]
Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including G1/S transition of mitotic cell cycle; heart development; and negative regulation of cardiac muscle tissue regeneration. Acts upstream of or within several processes, including negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation involved in prostate gland development; and positive regulation of microtubule polymerization. Located in cytosol and nucleus. Is expressed in several structures, including brain; genitourinary system; heart and pericardium; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdkn1b |
| Official Name | cyclin-dependent kinase inhibitor 1B [Source:MGI Symbol;Acc:MGI:104565] |
| Ensembl ID | ENSMUSG00000003031 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase inhibitor 1B |
| Synonyms | AI843786, Cdki1b, CDKN4, cyclin-dependent kinase inhibitor 1B, CYCLIN-DEPENDENT KINASE INHIBITOR P27, KIP1, MEN1B, MEN4, p27, P27kip, P27KIP1, P28-ICK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdkn1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- 3-10 helix
- Hsp70 protein binding
- protein kinase binding
- protein kinase inhibitor activity
- protein phosphatase binding
- nuclear localization sequence
- enzyme regulator activity
- protein binding
- enzyme activator activity
- cleavage site
- cyclin-dependent protein kinase activating kinase regulator
- cyclin-dependent kinase binding domain
- phosphorylation site
- cyclin-CDK binding domain
- cyclin binding
- cdk2 binding domain
- cyclin-dependent protein kinase inhibitor activity
- binding protein
- serine phosphorylation site
- chaperone binding
- cyclin-binding domain
- Cyclin-dependent kinase inhibitor
Pathways
Biological processes and signaling networks where the Cdkn1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Antiproliferative Role of TOB in T Cell Signaling
- Aryl Hydrocarbon Receptor Signaling
- Autophagy
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA damage-induced 14-3-3σ Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- ErbB2-ErbB3 Signaling
- Estrogen-mediated S-phase Entry
- HER-2 Signaling in Breast Cancer
- IL-7 Signaling Pathway
- Neuregulin Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- PTEN Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Small Cell Lung Cancer Signaling
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- lung adenocarcinoma formation
- non-squamous non-small cell lung cancer
- non-small cell lung cancer
- lung carcinoma process
- epithelial cancer
- lung cancer
- thoracic cancer
role in cell
- cell viability
- growth
- apoptosis
- expression in
- phosphorylation in
- cell death
- accumulation in
- survival
- activation in
- breakage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- perinuclear region
- basal bodies
- endosomes
- centrosome
- lysosome
- cytosol
- nucleoplasm
- nucleoli
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdkn1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- negative regulation of cell proliferation
- regulation of exit from mitosis
- positive regulation of cell proliferation
- cellular senescence
- response to amino acid stimulus
- epithelial cell proliferation involved in prostate gland development
- positive regulation of DNA replication
- response to xenobiotic stimulus
- placenta development
- regulation of cyclin-dependent protein kinase activity
- sensory perception of sound
- potassium ion transport
- heart development
- response to glucose stimulus
- nuclear export
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- negative regulation of transcription, DNA-dependent
- negative regulation of cell growth
- autophagic cell death
- G1/S transition of mitotic cell cycle
- cellular response to antibiotic
- regulation of cell cycle
- negative regulation of kinase activity
- cellular response to hypoxia
- positive regulation of microtubule polymerization
- negative regulation of epithelial cell proliferation involved in prostate gland development
- negative regulation of mitotic cell cycle
- positive regulation of protein catabolic process
- response to cadmium ion
- negative regulation of cyclin-dependent protein kinase activity
- response to peptide hormone stimulus
- negative regulation of phosphorylation
- cellular response to lithium ion
- Notch signaling pathway
- positive regulation of protein phosphorylation
- response to estradiol stimulus
- regulation of G1/S transition of mitotic cell cycle
- regulation of cell migration
- cellular response to organic cyclic compound
Cellular Component
Where in the cell the gene product is active
- nucleus
- endosome
- cytoplasm
- intracellular membrane-bounded organelle
- Cul4A-RING ubiquitin ligase complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ubiquitin protein ligase binding
- protein binding
- protein phosphatase binding
- cyclin-dependent protein kinase activating kinase regulator activity
- chaperone binding
- cyclin binding
- cyclin-dependent protein kinase inhibitor activity
- protein kinase inhibitor activity
- Hsp70 protein binding
- binding, bridging